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Robert J Ferrante Selected Research

Huntington Disease (Huntington's Disease)

6/2014Inhibition of mitochondrial protein import by mutant huntingtin.
2/2013MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition.
12/2012The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models.
10/2011The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity.
10/2011Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse.
1/2011Experimental models of HD and reflection on therapeutic strategies.
9/2010Safety and tolerability of high-dosage coenzyme Q10 in Huntington's disease and healthy subjects.
8/2010In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects.
7/2010Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease.
6/2009Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases.
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Robert J Ferrante Research Topics

Disease

48Huntington Disease (Huntington's Disease)
06/2014 - 01/2002
11Atrophy
07/2013 - 03/2002
10Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
08/2015 - 05/2002
9Neurodegenerative Diseases (Neurodegenerative Disease)
06/2014 - 03/2002
8Parkinson Disease (Parkinson's Disease)
12/2012 - 04/2003
5Disease Progression
07/2013 - 09/2003
5Body Weight (Weight, Body)
12/2010 - 10/2002
4Mitochondrial Diseases (Mitochondrial Disease)
06/2014 - 07/2002
3Nervous System Diseases (Neurological Disorders)
12/2010 - 05/2005
3Weight Loss (Weight Reduction)
06/2006 - 03/2002
2Inflammation (Inflammations)
07/2013 - 02/2007
2Gliosis
12/2010 - 04/2009
2Alzheimer Disease (Alzheimer's Disease)
04/2007 - 01/2007
2Multiple Sclerosis
07/2005 - 04/2003
2Stroke (Strokes)
06/2004 - 04/2003
2Ischemia
06/2004 - 07/2002
1Motor Neuron Disease (Primary Lateral Sclerosis)
04/2009
1Epilepsy (Aura)
01/2007
1Spinal Cord Injuries (Spinal Cord Injury)
01/2007
1Ischemic Stroke
01/2007
1Myelitis
07/2005
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
07/2005
1Demyelinating Diseases (Demyelinating Disease)
07/2005
1Lymphoma (Lymphomas)
06/2005

Drug/Important Bio-Agent (IBA)

12Proteins (Proteins, Gene)FDA Link
08/2015 - 03/2003
7polyglutamineIBA
06/2014 - 03/2003
6CaspasesIBA
07/2013 - 09/2003
6Cytochromes c (Cytochrome c)IBA
07/2013 - 01/2002
6CreatineIBA
06/2009 - 06/2003
6Neuroprotective AgentsIBA
06/2009 - 07/2003
5coenzyme Q10 (CoQ10)IBA
09/2010 - 03/2002
4Histone Deacetylase InhibitorsIBA
04/2009 - 10/2003
3Therapeutic UsesIBA
02/2013 - 03/2002
3Histones (Histone)IBA
10/2011 - 06/2005
3Adenosine Triphosphate (ATP)IBA
12/2010 - 06/2004
3Glutamic Acid (Glutamate)FDA Link
08/2010 - 02/2007
3AntioxidantsIBA
06/2009 - 03/2008
34-phenylbutyric acid (Buphenyl)FDA Link
04/2009 - 06/2005
3CystamineIBA
03/2008 - 10/2002
33-nitropropionic acidIBA
05/2007 - 07/2002
3Minocycline (Cyclops)FDA LinkGeneric
03/2006 - 05/2002
2Superoxide Dismutase-1IBA
08/2015 - 01/2012
2pyrazoloneIBA
08/2015 - 01/2012
2MelatoninIBA
07/2013 - 10/2011
2Butyric Acid (Butanoic Acid)IBA
02/2013 - 10/2003
2AdenineFDA LinkGeneric
01/2011 - 06/2009
2CytosineIBA
01/2011 - 06/2009
2GuanineIBA
01/2011 - 06/2009
2Biomarkers (Surrogate Marker)IBA
07/2010 - 04/2009
2Biological ProductsIBA
09/2008 - 03/2003
2Huntingtin ProteinIBA
08/2007 - 01/2005
2Succinate Dehydrogenase (Fumarate Reductase)IBA
05/2007 - 07/2002
2Histone Deacetylases (Histone Deacetylase)IBA
07/2005 - 10/2003
1AminesIBA
08/2015
1SaltsIBA
08/2015
1PyrazolonesIBA
08/2015
1Superoxide DismutaseIBA
08/2015
1Mitochondrial Proteins (Mitochondrial Protein)IBA
06/2014
1Caspase 1 (ICE Protease)IBA
07/2013
1Caspase 3 (Caspase-3)IBA
07/2013
1MT1 Melatonin ReceptorIBA
07/2013
1Melatonin Receptors (Melatonin Receptor)IBA
07/2013
1Dual Specificity Phosphatase 1IBA
02/2013
1Mitogen-Activated Protein KinasesIBA
02/2013
1Sirtuin 2IBA
12/2012
1CyclohexaneIBA
05/2012
1UridineIBA
12/2010
1pyrimidineIBA
12/2010
1NucleosidesIBA
12/2010
1Creatine Kinase (Creatine Phosphokinase)IBA
07/2010
1UbiquinoneIBA
06/2009
11- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
06/2009
1RiluzoleFDA LinkGeneric
04/2009
1Oxidants (Oxidizing Agents)IBA
12/2008
1NeurotoxinsIBA
03/2008
1Free Radical ScavengersIBA
03/2008
1N-acetylaspartate (N-acetyl aspartate)IBA
11/2007
1Messenger RNA (mRNA)IBA
08/2007
1Nortriptyline (Aventyl)FDA LinkGeneric
08/2007
1Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA
08/2007
1Nucleosomes (Nucleosome)IBA
05/2007
1Peptides (Polypeptides)IBA
04/2007
1Amyloid beta-PeptidesIBA
04/2007
1ChromatinIBA
12/2006
1Transcription Factors (Transcription Factor)IBA
06/2006
1alpha-SynucleinIBA
03/2006
1Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)IBA
10/2005
1theasinensin AIBA
07/2005
1trichostatin A (A 300)IBA
07/2005
1Pharmaceutical PreparationsIBA
07/2005
1NF-kappa B (NF-kB)IBA
06/2005
1PlicamycinFDA Link
11/2004
1Anti-Bacterial Agents (Antibiotics)IBA
11/2004
1rofecoxib (Vioxx)FDA Link
11/2004
1DisulfidesIBA
10/2004
1Cysteine (L-Cysteine)FDA Link
10/2004

Therapy/Procedure

10Therapeutics
06/2014 - 06/2003
3Drug Therapy (Chemotherapy)
03/2008 - 10/2003
2Oral Administration
07/2003 - 03/2002
1Immunotherapy
04/2007